山田哲也さんのセミナー
遺伝研にてハイデルベルク大学の山田哲也さんにご講演いただきました。
NIGセミナーページ: https://www.nig.ac.jp/nig/ja/research/seminer-ja?id=1715
- 開催日: 2025/06/02
- 時間: 13:30-14:30
- 場所: 図書館3階セミナー室 / Seminar room-Library 3F
- 演者: Tetsuya Yamada (Heidelberg University)
- 演題: The Evolution of Gene Regulation in Mammalian Cerebellum Development
- 要旨: Gene regulatory changes are considered major drivers of evolutionary innovations, including the cerebellum’s expansion during human evolution, yet they remain largely unexplored. In this study, we combined single-nucleus measurements of gene expression and chromatin accessibility from six mammals (human, bonobo, macaque, marmoset, mouse, and opossum) to uncover conserved and diverged regulatory networks in cerebellum development. We identified core regulators of cell identity and developed sequence-based models that revealed conserved regulatory codes. By predicting chromatin accessibility across 240 mammalian species, we reconstructed the evolutionary histories of human cis-regulatory elements, identifying sets associated with positive selection and gene expression changes, including the recent gain of THRB expression in cerebellar progenitor cells. Building on this framework, our ongoing work explores how transposable elements contribute to regulatory innovation in the mammalian cerebellum, with a particular focus on a primate-specific endogenous retroviruses co-opted into cell type-specific regulatory networks during hindbrain development. Collectively, our work reveals both the shared and lineage-specific regulatory programs governing cerebellum development, highlighting the previously unrecognized role of transposable elements in shaping mammalian brain evolution.